12/16/2020 0 Comments NIPT Testing in India - Indispensable Diagnostic tool used for Detecting Genetic Abnormalities During PregnancyDetecting genetic abnormalities during pregnancy: Genetic testing during pregnancy is an important perspective that mostly remains unexplored during pregnancy. Most genetic abnormalities can be detected using various diagnostic tools during pregnancy. The genetic testing tool estimates the risk of having a child with a genetic disorder, which can help the couple to make informed decisions. Invasive and Non-Invasive diagnostic tools are used to detect if the child has a certain genetic disorder after birth. These tools can also be used to detect miscarriage and the reason for stillbirth. Genetic abnormalities during pregnancy include extra or missing chromosomal material, leading to the development of different genetic disorders such as Down syndrome, Patau Syndrome, and Edward syndrome. Other than these three syndromes, several other genetic abnormalities can develop in a foetus during pregnancy. Early diagnosis or detection of these abnormalities can help the concerned doctor design a specific plan for managing the disorder. Non-Invasive Prenatal Testing (NIPT) in India: Non Invasive prenatal testing is an innovative genetic testing methodology that is being implemented by different genetic testing diagnostic companies to detect genetic abnormalities. In India, NIPT is being offered by the topmost genetic testing companies across the country. Genes2Me, one of the leading genetic testing companies, offers NIPT as a prominent tool for genetic testing during pregnancy. The name given to the test is ClaritNIPT. This test is recommended by top doctors and healthcare providers of the country. The test offers exceptional sensitivity and >99.9% accuracy in results, making it an inevitable test during pregnancy. The best part about this testing procedure is that it can be used as early as during the 10th week of pregnancy. A couple can get in-depth insights regarding genetic and chromosomal abnormalities by getting this test done early during pregnancy. Brief about NIPT: NIPT is a simple, non-invasive procedure that poses no risk to the developing baby and mother. The test uses the foetus’s cell-free DNA flowing in the maternal serum to check for chromosomal and genetic abnormalities. The test also avoids any risk of miscarriage or stillbirth, which can occur during invasive testing procedures. Non-invasive prenatal screening prominently looks for Trisomy 21 (Down syndrome), Trisomy 18 (Edward's Syndrome), and Trisomy 13 (Patau Syndrome). Genes2Me also offers full ClaritNIPT, which looks for other prominent aneuploidies and trisomy's other than the three mentioned above. This company's test also comes with a fast turnaround time of 8-10 days from the date of sample collection to report generation. Advanced and innovative Next Generation Sequencing (NGS) is used to process the patient's samples. In-depth reports are generated, which help the doctor and the patient manage the abnormalities and helps the couple make timely informed decisions. Pre and post genetic counselling option is also provided to the patients to be aware of the testing protocol and help them interpret results. NIPT is the best example of a chromosomal test that is performed during pregnancy. Early diagnosis using this testing protocol can help in decreasing the risk of genetic abnormality in the new-born. For more details, visit www.genes2me.com.
0 Comments
Mental Health: A Brief Overview Mental health is not being given due importance in public health systems. According to WHO (World Health Organization), almost 90 million Indians, that means almost 7.5 % of our population has some kind of mental disorder or disability. Are we investing enough to tackle mental illness? We are still not able to accept the social stigma that mental health is a serious problem, and we need to talk, understand and diagnose this issue in great depths. According to NIMHANS, a premier institute dealing with mental ailments says almost 150 million people in our country need medical attention, but only 30 million can get the desired treatment. This is threatening, and we as citizens of the nation need to spread awareness, and the government should invest in mental health for the betterment of the population. COVID and mental health: COVID-19 pandemic is having a severe impact on the mental health of different individuals. Because of lockdown, people are not able to move, and in their homes, they are getting depressed. Most of them are developing tendencies to commit suicides as almost one crore people have lost jobs due to this pandemic. Mental health is being neglected to a great extent which is going severe impact on the health of citizens. The focus needs to be shifted to this arena of public health so that people can be treated and cured of mental sickness. Tackling Mental health Issues: Talk, speak and listen are three major important parameters which are a hallmark in the betterment of mental health. Sensitization of communities and societies needs to be done to break the social stigma surrounding the patients suffering from mental health issues. Educating the society and connecting with the patients are two major steps which should be followed to prevent mental health issues in the youth. People with mental health ailments do not speak up due to which a large amount of intervention from the family members and friends are required to make his mental health better. Consulting a psychiatrist for the same should be done at earliest for diagnosis and treatment of mental health. How we act, our behaviour and our emotions decide whether we have mental health abnormality. People having mental health problems should be provided effective and safe treatment as patients suffering from physical diseases are provided. Awareness, proper intervention, education and meeting a doctor in case of mental health ailments and depression can only improve the situation of mental health in the country. Well, on this day, we should understand the importance of mental health and should educate the societies and communities on different mental health issues for the betterment of the nation. 8/16/2020 0 Comments Viral Collect Transport Kit - An innovation that carries VTM for collection and transport of CoronavirusViral Collect Transport kit:
Transportation of virus that causes COVID-19 is a tedious task. Clinical specimens containing viruses should be handled optimally from the collection site to the designated COVID-19 testing laboratory. Mishandling of the clinical specimens containing viruses could be dangerous to the medical professionals involved in transportation. Different swabs are used for the collection of coronavirus samples from the infected and asymptomatic individuals. Genes2me, Viral Collect transport Kit makes this tedious task more manageable as it drives innovation and has viral transport medium (VTM) that helps in the collection and transportation of viruses. Components of the Kit: Genes2Me Viral Collect Transport Kit contains polyester swabs and VTM that helps in the transportation of COVID-19 samples. This specific ready to use kit is designed in such a way that it maintains virus viability and also transfer virus in active form for effective and high-quality RNA isolation. The polyester swab's specific and peculiar design makes superior for effective elution of sample in the viral transport medium. The kit consists of 100 sterile specimen collection polyester swabs and 50 tubes of Viral Transport Medium. Viral Transport Medium (VTM): VTM carries antibiotics and necessary buffers that help control the growth of unwanted microorganisms and maintain an ideal pH for the sustenance of the virus during transport. Gentamicin and Amphotericin B have been added to the medium that inhibits pathogenic microorganism’s growth and proliferation. Sucrose forms an integral part as it plays a significant role in the maintenance of the medium's cryopreservative properties. The medium is isotonic, non-toxic, and does not pose any risk to host mammalian cells. This medium is also recommended by the Centre for Disease Control and World Health Organization for the collection and transportation of the virus that is responsible for causing COVID-19. Polyester Swabs: Polyester swabs present in the kit have the capacity to capture a significant amount of virus samples. The peculiar design contains polyester fibres that help in the effective collection and release of specimens collected in the medium. A moulded breakpoint is also included in the swab that helps to be broken in the tube carrying viral transport medium. Sample Collection: Once the sample is collected, it should be immediately transferred to the viral transport medium. To preserve the virus's integrity and viability, the clinical specimen should be transferred to the designated laboratory as soon as possible. If possible, carry the samples with icepack to maintain the sample's integrity for a prolonged period of time. The samples should be stored at -70 degrees Celsius if there is an unexpected delay in transporting samples from the collection site to the processing laboratory. Viral Collect Kit Accreditations: Genes2Me Viral Collect Transport Kit is indigenously made ‘Make in India’ and has received accreditations and certifications from ICMR-NIV, CE IVD, GMP and ISO 13485. For more details on Viral Collect kit, visit genes2me.com/covid19-solution/. About Genes2Me: GENES2ME is committed in creating a center of excellence in precision genetic testing and analysis by continually improving its services so as to meet and exceed globally recognized standards and to maximize customer satisfaction. Genes2Me, established in 2016, is now one of the leading companies in Molecular Diagnostics space in India. We are NABL accredited Diagnostic Lab, headquartered in Gurgaon, with a PAN India presence and clientele. For more details visit www.genes2me.com Coronavirus Detection:
Coronavirus is spreading its infectivity and spread all over the world. COVID-19 symptomatic and asymptomatic patients are rising daily in different regions present all over the globe. In the absence of a vaccine, testing and tracing are two critical parameters to control coronavirus spread. Real-time PCR-based detection is the gold standard methodology that is being followed to detect coronavirus in infected and asymptomatic cases. Rapid antibody tests are also being conducted to identify if the particular individual had a prior infection with the virus that causes COVID-19. These tests can be used in different hotspots of the nation for surveillance purposes. Clinical Specimens containing viral samples are transported in Viral Transport Medium to prevent viral entity and integrity for the purpose of RNA isolation. Viral Transport Medium (VTM) provides optimum conditions for storage and transportation of the virus from collection sites to the designated testing laboratories. Viral RNA Isolation: After samples reach the designated laboratories in the VTM, the sample is processed for further analysis. Viral RNA isolation is the preliminary step that is performed for Real-Time PCR analysis. Genes2me, one of the pioneers in advanced molecular diagnostics, has made viral RNA isolation easier by introducing the Mag RNA-II Viral RNA isolation kit. This specific RNA isolation kit is designed for viral RNA isolation from coronavirus clinical specimens. The kit is NIV-ICMR validated, CE-IVD approved, GMP approved, ISO 13485 certified, and manufactured in highly advanced facility. The kit is based on magnetic nanoparticle technology that helps 95-100% recovery of viral RNA for Real-Time PCR experiments, which is performed for the confirmation of COVID-19 in suspected, asymptomatic, and infected patients. Magnetic particles help in removing out the impurities such as proteins and other particles and filter out good quality RNA. Ideal and optimum RNA is adsorbed on the surface of magnetic nanoparticles, while the impurities are removed without getting adsorbed on the magnetic nanoparticles. The kit can be used for manual as well as automated extraction of RNA. The kit provides optimum quantity and quality of RNA in quick turnaround time. Carrier RNA is also included in the kit, which helps in enhancing the quality of eluted RNA. RNA can be extracted from different clinical specimens such as human serum, oral and nasal swabs, and bronchoalveolar lavage fluid. Nucleic acid (RNA) can be derived from low content biological samples. The approximate cost of the kit is ₹160+GST. For more details, please visit genes2me.com. Storage Conditions: The components of the Mag RNA-II Viral RNA isolation kit can be stored at 2 to 8 degrees Celsius. However, carrier RNA present in the kit needs to be stored -25 to -15 degrees Celsius. The kit has a validity of 12 months. Viral RNA Extraction and isolation is a crucial step in Coronavirus detection using Real-Time PCR technology. Genes2Me Mag RNA-II Viral RNA isolation kit provides optimum quality and quantity of viral RNA, which can be used for Real-Time PCR protocol. The kit will ease the process of COVID-19 diagnosis for hospitals and designated labs involved in COVID-19 testing. |
AuthorGenes2Me Pvt. Ltd. – Genetic Testing and Diagnostic Lab Archives
December 2020
Categories
|